Residence Inn By Marriott Jacksonville-Mayo Clinic Area Business photo

Residence Inn By Marriott Jacksonville-Mayo Clinic Area Exterior photo

Key details

About the Hotel

4905 San Pablo Road South, Jacksonville, 32224

Near Jacksonville Beach

Great

8.9

9.3

/10

4.6

4.5

Loved by Residence Inn By Marriott Jacksonville-Mayo Clinic Area guests

Free Mayo Clinic shuttle

Spacious suites

Kitchen facilities

Pet-friendly accommodation

High-quality breakfast

"Apartments are very spacious and beautiful, ultra clean and well maintained."

Lennox from United States

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"The layout of the room."

Zabia from United States

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"Every single thing about this hotel is PERFECT!"

ScottsdaleHP from United States

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"Great location near Florida Theater."

Alice G from United States

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"Breakfast was delicious. Real eggs!"

Deanna from United States

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3-star extended-stay hotel near Mayo Clinic with full kitchen suites

Rooms

Every suite includes a fully equipped kitchen with a full-size refrigerator, induction range, and microwave. Customizable in-suite care partnerships are available for guests requiring medical support. The air conditioning system is specially designed for enhanced air quality.

Location & Shuttle

The hotel is within a 2-minute drive of the Mayo Clinic Florida. A free shuttle service runs hourly to Mayo Clinic and local attractions. The St. Johns Town Center and Jacksonville Beach Golf Club are minutes away.

Dining & Breakfast

A complimentary breakfast buffet features American options and healthy selections daily. The on-site bar serves lunch and dinner with a menu including items like Buffalo chicken wings. Dinner orders can be placed at the bar counter and eaten in the lounge or guest room.

Pet-Friendly

The hotel accepts pets up to 50 pounds with designated grassy areas for walks. An outdoor picnic area and terrace provide space for guests traveling with dogs. The property offers a minimarket on site for pet supply purchases.

Highlights

Amenities: Medical guest lounge with air quality cooling system

Rooms: Full kitchen suites with customized care option

Location: 2-minute drive to Mayo Clinic with free shuttle

Dining: Complimentary healthy breakfast and bar dinner

Pet: Dog-friendly with grassy areas and minimarket

Must-do experiences

Visit the nearby Jacksonville Zoo & Gardens for unique wildlife.
Try a classic Reuben sandwich at the local favorite, The Great American.
Explore the historic Riverside Avondale area for charming boutiques.
Check out the Cummer Museum of Art & Gardens for stunning views.
Stroll along the scenic Jacksonville Riverwalk for sunset views.

Location: Perfect

9.3/10Review score

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Highlights from guests

Business FacilitiesWork Ready

The room layout was excellent for business, with a dedicated workspace and reliable connectivity.

Daniel from United States

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Room FeaturesHome Away

The kitchenette was fully furnished, providing a convenient option for preparing meals during our stay.

Sarah from Canada

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BathroomSpotless and Fresh

The bathroom was exceptionally clean and felt brand new, making for a very pleasant experience.

Michael from Australia

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Guest ParkingParking Solved

Parking was sufficient, even when we chose to drive ourselves instead of using the shuttle.

Emily from United Kingdom

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Select your room type

Residence Inn By Marriott Jacksonville-Mayo Clinic Area offers a range of rooms across the Sunshine State — from double rooms to family suites — complete with breakfast, flexible cancellations, and seasonal deals for your Florida stay

King Studio Suite Sofa Bed Roll Shower Mobility Accessible
2 persons
410 sq. feet
1 King-size bed and 1 Sofa bed
Air conditioning
Bathtub
room details
One-Bedroom Corner Suite Roll Shower Mobility Hearing Accessible
2 persons
650 sq. feet
2 King Size Beds
Air conditioning
Bathtub
room details
Corner King Studio Sofa Bed Hearing Accessible
2 persons
650 sq. feet
1 King-size bed and 1 Sofa bed
Air conditioning
Bathtub
room details

Show all rooms

Price and Room Availability Calendar

Check availability and prices for your dates now!

Amenities

Residence Inn By Marriott Jacksonville-Mayo Clinic Area offers amenities for your Florida getaway, from theme park days to coastal escapes

Facilities: Perfect

9.0/10Review score

General

No smoking on site
Wi-Fi
Parking
Safe deposit box
24-hour reception
Express check-in/ -out
Pets allowed
Rooms/ Facilities for disabled
Wheelchair access
Security
Luggage storage
Lift
Fireplace
Smoke detectors
Fire extinguishers
Key card access

Sports & Fitness

Fitness centre
Golf course

Guest Parking

Public parking is possible on site for free.

Services

Free shuttle service
Housekeeping
Laundry
Dry cleaning
Grocery shopping service
Shops/Commercial services

Dining

Bar/ Lounge area
Picnic area/ Tables

Business

Business centre
Meeting/ Banquet facilities
Fax/Photocopying

Children

Cots
Children's buffet
Board games

Facilities for people with disabilities

Toilet for disabled
Bathroom for disabled

Spa & Leisure

Heated swimming pool
Outdoor swimming pool
Sun loungers
BBQ facilities
Leisure/ TV room

Room features

Air conditioning
Heating
Sitting area
Terrace
Garden furniture
Tea and coffee facilities
Dining table

Bathroom

Free toiletries
Sink

Self-catering

Cookware/ Kitchen utensils

Media

Flat-screen TV
AM/FM alarm clock

Room decor

Carpeted floor

Residence Inn By Marriott Jacksonville-Mayo Clinic Area Location

4905 San Pablo Road South, Jacksonville, 32224

Map view

City landmarks

Amusement Park

Adventure Landing Jacksonville Beach

2.7 mi

Landmark

Harbor City Municipal Golf Course

1.3 mi

Landmark

Saint Ephrem Syriac Catholic Church

1.1 mi

Landmark

Windsor Parke Golf Club

1.8 mi

Golf Course

Marsh Landing Country Club

2.0 mi

Church

Church at Chets Creek

1.9 mi

Church

Hodges Boulevard Presbyterian Church

1.9 mi

Landmark

El Verde Yacht Basin

2.4 mi

Harbour

Jacksonville Beach Pier

3.9 mi

Landmark

Urban Golf

2.3 mi

Landmark

Beaches Fishing Charters

2.1 mi

Landmark

Regal Beach Boulevard 18

2.4 mi

Amusement Park

Shipwreck Island Water Park

2.6 mi

Landmark

Regal Cinema

2.4 mi

Park

Castaway Island Preserve

2.8 mi

Park

South Beach Park and Sunshine Playground

2.5 mi

Park

Mike McCue Park and Boat Ramp

2.6 mi

Landmark

Mind Bender Escape Rooms

2.8 mi

Landmark

Jacksonville Beach Action Sports Park

2.6 mi

Landmark

Jax Surf Training

2.6 mi

Landmark

Jacksonville Beach Golf Club

2.6 mi

Landmark

Paws Park

2.7 mi

Landmark

Cradle Creek Preserve

2.7 mi

Landmark

Beach Marine

2.6 mi

Landmark

Adventure Landing Water Park

2.6 mi

Landmark

Area 51 Laser Tag

2.7 mi

Landmark

Arcade

2.7 mi

Landmark

Batting Cages

2.7 mi

Landmark

Frog Hopper

2.7 mi

Landmark

Wingate Baseball Park

2.8 mi

Nearby

Hospital

Mayo Clinic Jacksonville

3400 ft

Restaurants

Bundy Cafe & Atrium

3000 ft

4500 San Pablo Rd S Mayo Clinic

Explore Jacksonville

Local Highlights

Mayo Clinic Jacksonville

12 minutes' walk

Renowned medical facility offering innovative patient care and health resources. Ideal for guests visiting for medical purposes.

Harbor City Municipal Golf Course

5 minutes' drive

A scenic 18-hole course perfect for golf enthusiasts. Offers a relaxed atmosphere and beautiful landscapes.

Windsor Parke Golf Club

10 minutes' drive

Challenging golf course nestled in nature, featuring beautiful views and well-maintained greens. Great for all skill levels.

Jacksonville Beach Pier

15 minutes' drive

Popular spot for fishing and scenic views of the Atlantic Ocean. Includes nearby dining and shopping for a full beach day.

Beaches Fishing Charters

10 minutes' drive

Exciting fishing charters that cater to both novices and experts. Book in advance for an unforgettable ocean adventure.

Cradle Creek Preserve

45 minutes' drive

Nature preserve with walking trails, great for bird-watching and relaxing strolls. A serene escape just a short drive away.

Shipwreck Island Water Park

10 minutes' drive

Family-friendly water park with thrilling slides and lazy rivers. A perfect spot for fun and excitement on a hot day.

Bundy Cafe & Atrium

10 minutes' walk

Charming cafe with a cozy atmosphere serving breakfast and brunch. Enjoy farm-to-table dishes and fresh ingredients.

Blue Accord Restaurant

5 minutes' drive

Casual dining with a menu full of Southern comfort food and fresh seafood. Perfect for a laid-back meal after a day out.

Salt Life Food Shack

15 minutes' drive

Lively spot offering seafood and tropical drinks. Great outdoor seating with ocean views, perfect for a fun evening.

Regal Beach Boulevard 18

10 minutes' drive

Modern cinema featuring the latest films. Offers comfortable seating and a variety of snack options.

Mind Bender Escape Rooms

10 minutes' drive

Exciting escape room challenges for friends and families. Great team-building activity for all ages.

Getting around Florida

City Centre
Jacksonville 35 min · 14.1 mi
Airports
Jacksonville International (JAX) 67 min · 27.7 mi
St Augustine (UST) 71 min · 29.2 mi
Train
Jacksonville Electric Authority Southside Generating Station Wharf 30 min · 12.3 mi
Union Station 36 min · 14.9 mi